Bruno Siqueira Mietto

Bruno Siqueira Mietto, PhD

"Bruno Mietto"

Professor of Cell Biology NIH, Nichd/nat'L Inst of Child Health & Human Devel

Washington, District of Columbia United States




Bio

Cellular biology reveals the fundamental principles of life and provides a powerful lens for understanding how diseases emerge. I am driven by the complexity of this health-disease interplay, where subtle disruptions in cellular function can lead to profound human disorders. My laboratory focuses on elucidating how the cells of the peripheral nervous system (PNS) operate under both physiological and pathological conditions, with particular emphasis on how diverse stressors contribute to PNS damage and dysfunction, and their implications for recovery and neuropathy. This research direction evolved from my early clinical practice with neurological patients to laboratory-based investigations using rodent and cellular models to study Wallerian degeneration, injury and repair mechanisms, and neuro-glia-immune responses. I employ multidisciplinary methods that integrate biochemistry, molecular and cellular biology, comprehensive histology with advanced imaging modalities, electrophysiology, and rodent behavioral testing. In recent years, my research has concentrated on leprosy-induced neuropathy and the consequences of Mycobacterium leprae infection on host-cell metabolism. Another area of investigation focuses on iron metabolism in the PNS and the impact of disrupted iron homeostasis on cellular stress and neurodegeneration.
Neuroscience Sub-Discipline
Cellular and Molecular Neuroscience
Disorders of the Nervous System
Neuroregeneration and Repair
Techniques
Biochemistry
Cell Culture
Histochemistry and Tracing
Imaging (microscopy)
Molecular Approaches
Other

Awards & Fellowships

Award NameAward Participant StatusEnd Date
Latin American Training Program - FellowsFellow3/20/2018
SfN-IBRO International Travel AwardsWinner12/31/2016
Latin American Training Program - AssociatesAssociate8/1/2016

SfN Service History

CommitteeTitleMember Status
Trainee Professional Development Awards Selection CommitteeMemberPast
Professional Development Committee MemberPast
NSP Selection CommitteeMemberPast