Janet A Clark, PhD

Janet A Clark, PhD

"Jan"

Regular Training Director National Institute of Mental Health Division of Intramural Research

Bethesda, MD United States




Bio

As an accomplished Ph.D. Neuropharmacologist with 10 years of drug development experience in a major pharmaceutical company, I offer the following; • Experience in neuroendocrinology, psychiatry, and neurodegenerative disease areas • Drug discovery experience including target identification and validation, pharmacodynamic marker identification and validation, pharmacodynamic assay development and translational biomarker work • Experience with in vivo neuroscience efficacy models • Management experience includes leading a discovery team consisting of a senior scientist and 2-3 associates, working in and leading cross-functional teams of biologists, medicinal chemists, drug metabolism and pharmacokinetics and clinical scientists on drug discovery projects directed at target identification, lead optimization and advancing lead molecules into the clinic • Extensive experience with assessing in-licensing opportunities and external collaborations, including participating in face-to-face meetings with potential in-licensing/collaborative partners in the therapeutic areas of Depression/Anxiety and Schizophrenia • Research skills and technical expertise include: recombinant DNA technology (restriction enzyme analysis, bacterial expression, plasmid purification, RNA / DNA isolation, PCR, primer design, Southern/Northern analysis, RACE, site-directed mutagenesis); cell culture; organotypic culture (hippocampal and corticostriatal); denaturing and non-denaturing PAGE; western blot; stable and transient transfections; immunohistochemistry; immunoprecipitations; ELISA; cell-based assays; radioenzymatic assays; immunofluorescence; real-time PCR; DNA arrays; receptor binding; agonism, antagonism, inverse agonism assay development; rodent brain microdissections; intravitreal injections and ophthalmic dissections; fluid biomarkers; and transcranial magnetic stimulation in rat
Neuroscience Sub-Discipline
Behavioral Neuroscience
Cellular and Molecular Neuroscience
Neuroendocrinology
Neuropharmacology and Neurochemistry

Committee Participation

CommitteeTitleMember Status
Professional Development Committee MemberPast
NSP Selection CommitteeMemberCurrent
Neuroscience Training Committee (NTC)MemberCurrent