Dr Hof is Regenstreif Professor and Vice-Chair of the Department of Neuroscience at Mount Sinai School of Medicine (MSSM) where he directs the Neurobiology of Aging Laboratories and the Computational Neurobiology and Imaging Center (CNIC). He is internationally known for his work in quantitative neuropathology of normal aging and dementia. He is the author of more than 300 papers in brain aging and in comparative neuroanatomy. His research is directed towards the study of selective neuronal vulnerability in dementia using classical neuropathological as well as modern quantitative immunohistochemical methods. He has developed quantitative, detailed, and cohesive definition of neuronal susceptibility to degeneration in the cerebral cortex, by extending data on Alzheimer's disease to other dementing disorders as well as animal models of age-related illnesses, and by defining the key neurochemical and morphological characteristics linked to relative vulnerability (or resistance to degeneration) of identified neuronal populations at multiple levels of resolution. In addition, Dr Hof has extensive expertise in neurostereology, morphometry, and primate and rodent brain anatomy. He has published histologic and MR microscopy mouse brain atlases and is one of the leaders in the development of the NeuroStudio software that provide automatic 3D high-resolution reconstruction of neuronal morphologies and analysis of their morphometric characteristics. Dr Hof was the co-founder with the late Dr Wearne of CNIC at MSSM and he works on many aspects of quantitative brain morphology over the past 2 decades. Finally Dr Hof is a comparative anatomist and studies the evolution of the neocortex with a special emphasis on great apes and large marine and terrestrial mammalian species. He maintains of collection of brain specimens, several hundreds strong.