Charalambos Costas Charalambous

Charalambos Costas Charalambous, PhD


Regular Medical Instructor Duke University

Durham , NC US


I am a motor neuroscientist with emphasis on the neuro-physio-biomechanical and behavioral mechanisms of motor recovery and rehabilitation. The overarching aim of my research is to understand the plasticity of the descending motor pathways as it relates to sensorimotor function of walking and how to harness that plasticity to promote walking recovery in clinical cohorts. My research vision is (1) to fill the existing knowledge gap on the role of the motor descending drives during locomotion and subsequently (2) to progress and develop mechanism-driven strategies to enhance locomotor performance and recovery in patients with motor injuries, so they can achieve safe, independent, and efficient walking for longer, healthier lives. My two current lines of research are to systematically examine (1) how descending motor pathways contribute to sensorimotor control of walking in both neurotypical adults and clinical cohorts, and (2) how non-invasive brain stimulation strategies, such as transcranial Alternate Current Stimulation, can modulate these pathways to improve the sensorimotor control of human walking after stroke. My areas of research expertise are the assessment of the neuromotor axis of the upper and lower extremities, neuromechanical analysis of human movement, human locomotor control and learning, tracking of the neural and motor recovery in clinical cohorts, application of neuromodulation techniques in neurorehabilitation, and use of computational approaches for the analysis of neurophysiological and neuromechanical data.

Neuroscience Sub-Discipline
Behavioral Neuroscience
Cognitive Neuroscience
Computational Neuroscience and Modeling
Disorders of the Nervous System
Evolutionary and Comparative Neuroscience
Motor Systems Neuroscience
Neural / Synaptic Structure and Function
Neuroregeneration and Repair
Neuroscience of Aging
Sensory Systems Neuroscience
Analysis of Behavior and Cognition in Humans
Computation, Modeling, and Simulation
Data Analysis and Statistics
Electrophysiology (unit activity)
Imaging (PET, fMRI, etc)
Therapeutic Techniques
Research Areas
Motor Systems
Neural Excitability, Synapses and Glia

SfN Service History

CommitteeTitleMember Status
Trainee Advisory CommitteeMemberCurrent